József Prechl

Curriculum Vitae

Personal information
First name / Surname		József Prechl
E-mail		info@abc-arrays.com
Date of birth		1969
Gender		Male

Work experience
Dates		01 January 2008 – >
Occupation or position held		Research professor
Dates		01 January 2004 – 31 December 2007
Occupation or position held		Research associate
Dates		01 January 2000 – 31 December 2003
Occupation or position held		Research assistant
Name and address of employer		Prof. Anna Erdei Hungarian Academy of Sciences Subsidised Research Units at Eötvös Loránd University, Department of Immunology 1/C, Pázmány Péter s., H-1117 Budapest, Hungary E-mail: anna.erdei@freemail.hu Website: http://immunologia.elte.hu
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Dates		16 April 1996 - 01 July 1997
Occupation or position held		Post-doctoral fellow
Main activities and responsibilities		Recombinant antibody production
Name and address of employer		Prof. Peter Capel AZU, Utrecht, The Netherlands
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Dates		2004, 2005, 2006; few months each
Occupation or position held		Visiting Scientist
Name and address of employer		Prof. Matyas Sandor University of Wisconsin, Madison Department of Pathology and Laboratory Medicine E-mail: msandor@wisc.edu Website: http://labs.pathology.wisc.edu/fabry-sandor/

Education and training
Dates		01 September 1997 - 30 August 2000
Principal subjects / occupational skills covered		Immunology PhD student ELTE, Department of Immunology
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Dates		1987-1993
Title of qualification awarded		MD Student
Principal subjects / occupational skills covered		General Medicine
Name and type of organisation providing education and training		Semmelweis University Medical School Budapest, Hungary

Personal skills and competences
Mother tongue		Hungarian
Other language(s)		English Italian German

Scientific achievements
Membership		Hungarian Society for Immunology Hungarian Biochemical Society
Patent		WO2008007159 „Measurement of complement activation products on antigen arrays ”

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Publications

Papers:

Krisztián Papp, Péter Végh, Kata Miklós, Julianna Németh, Klára Rásky, Ferenc Péterfy, Anna Erdei, József Prechl: "Detection of complement activation on antigen microarrays generates functional antibody profiles and helps characterization of disease associated changes of the antibody repertoire "Journal of Immunology 181 :8162-8169.
Krisztián Papp, Zsuzsanna Szekeres, Anna Erdei, József Prechl: “Two-dimensional immune profiles improve antigen microarray-based characterization of humoral immunity” Proteomics 2008. 8:2840-2848.
Voynova, E., Tchorbanov, A., Prechl, J., Nikolova, M., Baleva, M., Erdei, A., and Vassilev, T.: "An antibody-based construct carrying DNA-mimotope and targeting CR1(CD35) selectively suppresses human autoreactive B-lymphocytes" 2008, Immunol.Lett. 116:168-173.
Molnar, E., Prechl, J., and Erdei, A.: "Novel roles for murine complement receptors type 1 and 2 II. Expression and function of CR1/2 on murine mesenteric lymph node T cells." 2008, Immunol.Lett. 116:163-167 .
Molnar, E., Erdei, A., and Prechl, J.: "Novel roles for murine complement receptors type 1 and 2 I. Regulation of B cell survival and proliferation by CR1/2." 2008, Immunol.Lett. 116:156-162.
Isaak, A., Gergely, P., Jr., Szekeres, Z., Prechl, J., Poor, G., Erdei, A., and Gergely, J.: "Physiological up-regulation of inhibitory receptors Fc gamma RII and CR1 on memory B cells is lacking in SLE patients." 2008, Int.Immunol. 20:185-192.
Krisztián Papp, Péter Végh, József Prechl, Krisztina Kerekes, János Kovács, György Csikós, Zsuzsa Bajtay, Anna Erdei: "B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity” Molecular Immunology 2008. 45:2343–2351
Gergely, P., Jr., Isaak, A., Szekeres, Z., Prechl, J., Erdei, A., Nagy, Z. B., Gergely, J., and Poor, G. :"Altered expression of Fcgamma and complement receptors on B cells in systemic lupus erythematosus." 2007, Ann.N.Y.Acad.Sci. 1108:183-192.
Prechl, J., Molnar, E., Szekeres, Z., Isaak, A., Papp, K., Balogh, P., and Erdei, A.: "Murine CR1/2 targeted antigenized single-chain antibody fragments induce transient low affinity antibodies and negatively influence an ongoing immune response." 2007, Adv.Exp.Med.Biol. 598:214-225.
Balogh, A., Szabo, M., Kelen, D., Bokodi, G., Prechl, J., Bosze, S., and Vasarhelyi, B.: "Prohepcidin levels during human perinatal adaptation. "2007, Pediatr.Hematol.Oncol. 24:361-368.
Angyal, A., Prechl, J., and Sarmay, G.: "Possible therapeutic applications of single-chain antibodies in systemic autoimmune diseases." 2007, Expert.Opin.Biol.Ther. 7:691-704.
Krisztián Papp, Zsuzsanna Szekeres, Nóra Terenyi, Andrea Isaák, Anna Erdei, József Prechl: "On-chip complement activation adds an extra dimension to antigen microarrays" Molecular & Cellular Proteomics 2007. 6:133-140.
Isaak, A., Prechl, J., Gergely, J., and Erdei, A.:"The role of CR2 in autoimmunity. 2006, Autoimmunity 39:357-366."
Terenyi, N., Prechl, J., and Erdei, A.:" The role of the complement system in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis." 2006, Adv.Exp.Med.Biol. 586:177-188.
Ivanovska, N., Tchorbanov, A., Prechl, J., Maximova, V., Voynova, E., and Vassilev, T. L.:"Immunization with a DNA chimeric molecule encoding a hemagglutinin peptide and a scFv CD21-specific antibody fragment induces long-lasting IgM and CTL responses to influenza virus." 2006, Vaccine 24:1830-1837.
Mastellos, D., Prechl, J., Laszlo, G., Papp, K., Olah, E., Argyropoulos, E., Franchini, S., Tudoran, R., Markiewski, M., Lambris, J. D., and Erdei, A.: Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays." 2004, Mol.Immunol. 40:1213-1221.
Molnar, E., Prechl, J., Isaak, A., and Erdei, A.:" Targeting with scFv: immune modulation by complement receptor specific constructs." 2003, J.Mol.Recognit. 16:318-323.
Erdei, A., Prechl, J., Isaak, A., and Molnar, E.:" Regulation of B-cell activation by complement receptors CD21 and CD35."2003, Curr.Pharm.Des 9:1849-1860.
Andrasfalvy, M., Prechl, J., Hardy, T., Erdei, A., and Bajtay, Z.:" Mucosal type mast cells express complement receptor type 2 (CD21)." 2002, Immunol.Lett. 82:29-34.
Jozsi, M., Prechl, J., Bajtay, Z., and Erdei, A.:" Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes." 2002, J.Immunol. 168:2782-2788.
Prechl, J., Baiu, D. C., Horvath, A., and Erdei, A.:" Modeling the presentation of C3d-coated antigen by B lymphocytes: enhancement by CR1/2-BCR co-ligation is selective for the co-ligating antigen." 2002, Int.Immunol. 14:241-247.
Kerekes, K., Cooper, P. D., Prechl, J., Jozsi, M., Bajtay, Z., and Erdei, A.:" Adjuvant effect of gamma-inulin is mediated by C3 fragments deposited on antigen-presenting cells." 2001, J.Leukoc.Biol. 69:69-74.
Prechl, J. and Erdei, A.:" Immunomodulatory functions of murine CR1/2." 2000, Immunopharmacology 49:117-124.
Radvany, Z., Darvas, Z., Kerekes, K., Prechl, J., Szalai, C., Pallinger, E., Valeria, L., Varga, V. L., Sandor, M., Erdei, A., and Falus, A.:" H1 histamine receptor antagonist inhibits constitutive growth of Jurkat T cells and antigen-specific proliferation of ovalbumin-specific murine T cells." 2000, Semin.Cancer Biol. 10:41-45.
Kurucz, I., Tombor, B., Prechl, J., Erdo, F., Hegedus, E., Nagy, Z., Vitai, M., Koranyi, L., and Laszlo, L.:" Ultrastructural localization of Hsp-72 examined with a new polyclonal antibody raised against the truncated variable domain of the heat shock protein." 1999, Cell Stress.Chaperones. 4:139-152 .
Prechl, J., Tchorbanov, A., Horvath, A., Baiu, D. C., Hazenbos, W., Rajnavolgyi, E., Kurucz, I., Capel, P. J., and Erdei, A.:"Targeting of influenza epitopes to murine CR1/CR2 using single-chain antibodies." 1999, Immunopharmacology 42:159-165.
Szaleczky, E., Prechl, J., Feher, J., and Somogyi, A.:" Alterations in enzymatic antioxidant defence in diabetes mellitus--a rational approach." 1999, Postgrad.Med.J. 75:13-17.
Baiu, D. C., Prechl, J., Tchorbanov, A., Molina, H. D., Erdei, A., Sulica, A., Capel, P. J., and Hazenbos, W. L.:" Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors." 1999, J.Immunol. 162:3125-3130.
Kerekes, K., Prechl, J., Bajtay, Z., Jozsi, M., and Erdei, A.:" A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells." 1998, Int.Immunol. 10:1923-1930.
Pusztai, P., Prechl, J., Somogyi, A., Szaleczky, E., and Feher, J.:" [Experimental models in research of the pathomechanism of diabetes mellitus]." 1996, Orv.Hetil. 137:1865-1869.
Prechl, J., Somogyi, A., Pusztai, P., Kocsis, I., Blazovics, A., Boros, I., and Feher, J.:" [Free radical reactions in juvenile rats treated with streptozotocin]." 1996, Orv.Hetil. 137:979-982 .
Somogyi, A., Pusztai, P., Prechl, J., and Feher, J.:" [Hypothetical connection between diabetes mellitus and free radical reactions in arteriosclerosis]." 1994, Orv.Hetil. 135:1815-1818.
Prechl, J., Papp, K., Vegh, P., and Erdei, A.:" On-chip complement activation for functional profiling of serum antibodies on antigen microarrays." 2007, Molecular Immunology 44:3917-3917.
Papp, K., Prechl, J., Szekeres, Z., and Erdei, A.:" On-chip complement activation is a suitable technique for the simultaneous detection of the presence and complement activating properties of autoantibodies." 2007, Molecular Immunology 44:3953-3953.
Erdei, A., Molnar, E., Isaak, A., Szekeres, Z., Papp, K., and Prechl, J.:" Novel roles of CR1/2 on B lymphocytes." 2007, Molecular Immunology 44:166- 166.
Bosze, S., Mezo, G., Schlosser, G., Pocsfalvi, G., Balogh, A., Prechl, J., Hudecz, F., and Vasarhelyi, B.:" Determination of hepcidin content of urine using ELISA and mass spectrometry." 2006, Journal of Peptide Science 12:228-228.
Hargitai, R., Prechl, J., and Torok, J.:" Maternal immunoglobulin concentration in Collared Flycatcher (Ficedula albicollis) eggs in relation to parental quality and laying order." 2006, Functional Ecology 20:829-838.
Adori, M., Balogh, A., Weiszhar, Z., Prechl, J., Matko, J., and Laszlo, G.:" Studies on cell specific expression, structure and membrane localization of a late lymphoid activation antigen Ly77 (GL7)." 2005, Febs Journal 272:223-223.
Terenyi, N., Prechl, J., and Erdei, A.:" MOG peptide specific antibody response in the mouse model of multiple sclerosis shows no correlation with the severity of the disease." 2005, Febs Journal 272:293-293.
Virag, V., Prechl, J., and Erdei, A.:" Production of tetrameric single-chain antibodies using enzymatic biotinylation." 2005, Febs Journal 272:519-520.
Szekeres, Z., Isaak, A., Prechl, J., and Erdei, A.:" Generation of a fusion protein containing DNA-like peptide and a single chain antibody." 2005, Febs Journal 272:529-529.
Prechl, J., Molnar, E., Papp, K., Isaak, A., Verbeek, J. S., and Erdei, A.:" A CR1/2 specific single-chain antibody fragment inhibits apoptosis and enhances proliferation of splenic B cells." 2004, Molecular Immunology 41:295-296.
Prechl, J.:" Modulation of the immune response by complement receptor targeted recombinant antibodies." 2004, Tissue Antigens 64:334-334.
Gombos, I., Bacso, Z., Detre, C., Szabo, G., Andrasfalvy, M., Prechl, J., and Matko, J.:" Flow cytofluorimetric analysis of differential detergent resistance (FCDRA): A rapid test of raft-association of membrane proteins." 2004, Cytometry Part A 59A:30-30.
Somogyi, A., Szaleczky, E., and Prechl, J.:" Inhibition of advanced glycated end-products - Response." 1999, Postgraduate Medical Journal 75:446- 447.
Prechl, J., Horvath, A., Kurucz, I., Baiu, D. C., Tchorbanov, A., Hazenbos, W., Rajnavolgyi, E., Erdei, A., and Capel, P. J. A.:"Targeting of influenza epitopes to murine CR1,2 using scFv antibodies." 1998, Molecular Immunology 35:387-387.